The 0.5mg assessment dose at the beginning is particularly valuable for researchers who have never used any incretin-based peptide before, as it reveals individual sensitivity before committing to the standard 1mg starting dose
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Drug interactions of exenatide were described in eight manuscripts [13, 20,21,22,23, 25, 33, 34], liraglutide in five [17, 19, 24, 26, 34], semaglutide in three [16, 18, 27], and lixisenatide, dulaglutide and albiglutide in two each [14, 15, 29,30,31,32] and synthetic GLP1 in one manuscript [28]
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Summary: GLP-1 receptor agonists commonly cause acid reflux and heartburn by delaying gastric emptying, which increases stomach pressure and promotes reflux of stomach contents into the oesophagus