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If needle-free convenience, room-temperature storage, and potentially lower cost matter most, orforglipron represents a genuine step forward for the field
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For patients, it raises important questions: how does this approach compare with current major therapies such as semaglutide and tirzepatide
It also acts as an inhibitory neurotransmitter in the central nervous system, which can have mild calming effects
[7] [8] GLP-1 receptor agonists (such as semaglutide, liraglutide, and dulaglutide) are now widely prescribed medications for type 2 diabetes and obesity management, approved by the MHRA and recommended in NICE guidelines (NG28 for type 2 diabetes
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