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Data availability Because the model population is derived from de-identified registry data, the data cannot be made available owing to privacy concerns

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The candidate will be developed as both an oral formulation (PN-477o) for once-daily dosing and a subcutaneous version (PN-477sc) for once-weekly injections

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Side effects Because retatrutide stimulates GLP-1 receptors, the side effects are broadly similar to current GLP-1 medicines