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Those with conditions like IBS, IBD, gastritis, or ulcers often use oral protocols with doses of 0.5 to 1 mg daily to maximize local gastrointestinal exposure

Lamas et al., 2013)

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Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic -cells

This phenomenon is explained by the BurtonIngold hypothesis, whereby -carotene shifts from an antioxidant to a pro-oxidant under high oxygen tension, as found in the pulmonary environment of smokers