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Additionally, EGCG, through endonuclease ERCC1 inhibition, decreases the DNA repair in human cancer cells, through synergizes the therapeutic effect of anticancer drugs (e.g., cisplatin, irinotecan) 153,154

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It is worth noting that there is still a need for careful consideration as to whether to use Se-containing compound to intervene in the development and progression of cancer

One practical downside is that higher-dose use doesnt align neatly with these intervals

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