A post hoc analysis in Japan indicated that the combination of SGLT2i and GLP-1RA was superior to monotherapy in improving liver function parameters (ALT, AST), hepatic steatosis index (HSI), and fibrosis index (FIB-4), suggesting complementary mechanisms between the two
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Commonly used in laboratory research, it is being investigated for pigmentation biology, melanocortin signalling, and neuroendocrine pathways
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One of the most prominent issues is the high rate of adverse events such as nausea, diarrhea, constipation, abdominal pain, and other gastrointestinal adverse effects
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