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Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1 activation on macrophages
these, however, are believed to be nerves of ordinary sensation and not gustatory
We propose that the effects of an incretin-based therapy (tirzepatide) on food preoccupation may be associated with modulation of aberrant activity within this key hub of human mesolimbic circuitry
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Other common effects include digestive changes, decreased appetite (the desired effect), fatigue, and minor injection site irritation
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