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Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA
The liver, which houses the highest glutathione concentrations and performs extensive detoxification work, increases its activity during sleep when digestive demands are minimal and energy can be directed toward cellular maintenance
Mammalian lipids: structure, synthesis and function
Retinoids accelerate skin cell turnover and clear clogged pores
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