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Impairment of peripheral nerve regeneration by insufficient activation of the HGF/c-Met/c-Jun pathway in aged mice

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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

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4), low-dose ZIL did not affect the expression levels of undifferentiated markers ( Oct3/4 and Nanog ), while DMSO downregulated them in a dose-dependent manner (Fig