We implemented the SQ infusion of OHCbl using a SQ catheter system together with a small, portable pump in four patients with cobalamin-related remethylation disorders in whom frequent IM injections were not or no longer feasible
The key point: the best option depends on the reason for low B12 and your clinical context
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The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place
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It is sold as a research chemical NNMT inhibition has broad implications : NNMT is involved in multiple metabolic pathways beyond NAD+, including methylation balance, polyamine metabolism, and one-carbon metabolism
