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These medicines have well-characterised safety profiles and are prescribed within a structured clinical pathway that includes monitoring and follow-up

Key Research Findings Weight Loss Efficacy: In phase 2 trials, Retatrutide outperformed comparators like semaglutide and tirzepatide in weight reduction, with a linear dose-response relationship up to 12 mg

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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (30, 112, 176, 207)

Significant reductions in luteinizing hormone (LH), androgen levels, and the LH/follicle-stimulating hormone ratio were observed