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Another limitation of the current model is that it only focuses on predicted hepatocyte cell state distribution and lobular necrosis pattern using four representative overdose cases, rather than validation of the model using clinical biomarkers, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), or the international normalized ratio (INR)

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[13] Both ingredients are well-supported, and both have gaps in the clinical literature

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