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High levels of oxidative stress may contribute to ALS onset, increasing motoneurons death, and heavy metals may be a cause for the increase of ROS

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Increased GH-release: K Raun et al

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Long-range spread may be dominated by redox excitability and local ROS re-amplification, whereas short-range propagation may be governed primarily by membrane biophysics, intercellular spacing, and junctional architecture, which together define a continuum of spatial coupling mechanisms

The studies are vague or uncited