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To address these limitations, insulin analogs with modified amino acid sequences and structures have been developed, offering improved pharmacokinetic and pharmacodynamic profiles
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When administered properly, it is considered very safe and well-tolerated, with no stimulants or harsh ingredients
Therefore, this review aims to synthesize the evidence on the mechanistic expansion of GLP-1RAs from metabolic regulators to systemic modulators of inflammation, autophagy, and organ protection, and explores their therapeutic repurposing across diseases