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Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss

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GLP-1 receptors are expressed on various immune cells, including T lymphocytes and macrophages, and preclinical research has identified potential anti-inflammatory effects of GLP-1 signaling, but the clinical significance of these observations remains uncertain

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Activating various enzymes, such as phospholipase A2 (PLA2) and glycoprotein kinases, elevates intracellular calcium levels