Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)
In the brain of an adult living with depression, something has gone awry with the plasticity and the protection of the neuronal population, says McIntyre
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IGF-1 LR3 can also be administered intramuscularly [12]
Interestingly, the paclitaxel-induced allodynia could be reduced by administering PEA through multiple routes, e.g., intrathecal, intraplantar and directly into the brain via intracerebroventricular injection, evidence that PEA can act on both the peripheral and central nervous system to achieve therapeutic efficacy