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Abstract Purpose Bispecific antibody-drug conjugates (BsADCs) represent a promising strategy to overcome limitations of conventional ADCs in breast cancer, such as tumor heterogeneity and inefficient internalization

Next, to explore whether the X-IPA system could detect changes to gut permeability induced by intestinal metabolites, gut organ cultures were infused with putrescine, a polyamine compound produced by the gut microbiota which we recently identified as a potent disruptor of the intestinal epithelial barrier 10

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The utilization of the nanohybrid system aimed to specifically target folate receptor-overexpressing HeLa cells, facilitating the efficient delivery of doxorubicin to cancer cells

This dose is also close to RSV regimens previously reported in VPA-induced animal models of ASD, in which RSV was administered at approximately 3.6 mg/kg for 1213 days (Fontes-Dutra et al., 2018