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The incretin hormones have now established their role as effective glucose-lowering agents

PMC 281544

Slow titration, smaller meals, skipping fried and very fatty foods during dose increases, and steady hydration handle most of it

[59] [60] Injection side effects include skin rash, itching, chills, fever, hot flushes, nausea and dizziness

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Taken together, these guidelines reinforce SGLT2i as the backbone of CKD management across diabetic and non-diabetic disease, with GLP-1 RAs positioned as additive therapy for appropriately selected patients, rather than as replacements