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Safety in patients with existing mild-moderate liver disease Correlation between weight loss and estimated liver fat reduction TRIUMPH-2 (Ongoing, Expected 2026) Primary Endpoints: Weight loss in diabetic patients HbA1c reduction Secondary Endpoints (Liver): Liver enzymes Metabolic markers Diabetic Population Note: Higher prevalence of MASLD/NASH (~40-50%), so liver benefits particularly important in this group

Headache or fatigue Mild headache or tiredness has been reported by some patients, typically easing as the body adjusts

This classification reflects scientific caution rather than proven harm, but it's why most reproductive endocrinologists recommend stopping the medication 23 months before trying to conceive

Likewise, our in vivo study demonstrated that Ach-induced endothelium-dependent vasodilation was impaired in HFD-fed ApoE / mice

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