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There are a few common, mild side effects associated with B12 shots, including: Mild diarrhea, itching, nausea and vomiting, dizziness, headaches, and hot flashes Redness or swelling at the injection site Temporary soreness at injection site Serious side effects are rare but require immediate medical attention

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No data suggests that very high supplementation levels are any more effective at boosting a persons immune system or bodily functions if they do not have a vitamin B12 deficiency