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That selectivity matters clinically because chronic cortisol elevation would counteract the anabolic intent of GH stimulation
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Thus, factors regulating the neuronal circuitry between brain regions that contain BDNF-producing neurons (i.e., the entorhinal cortex) and regions that lack BDNF-producing neurons (i.e., the hippocampus) play a critical role in governing BDNF trafficking in the brain
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