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Several ionic mechanisms such as non-selective cation channel, voltage-dependent potassium channel, and TRPC5 channel may be associated with activation of GLP-1R-induced electrophysiological effects (Figure 1A)

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The most common include: Nausea Vomiting Diarrhea Reduced appetite Less common side effects include: Dizziness Increased heart rate Headaches In rare cases, GLP-1 agonists may cause pancreatitis, allergic reactions and low blood sugar levels

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