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doi:10.1089/thy.2016.0457 [5] Moleti M, Di Mauro M, Sturniolo G, Russo M, Vermiglio F
SURMOUNT-1 (72-week randomized study, adults without diabetes): tirzepatide produced an average loss of 15.0% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) of body weight, versus 3.1% with placebo, under a similar lifestyle-intervention protocol
The enzyme tyrosinase darkens skin by causing pigmentation by way of oxidation, as in the browning of peeled fruits and vegetables
This effect means food and fluids remain in the stomach longer, which can influence both appetite and fluid intake patterns
Refrigerated at 28 C, used within approximately four weeks, and protected from repeated freezethaw cycles
Patients currently using AOM tirzepatide may need to switch to AOM semaglutide to maintain insurance coverage of the medication, while those wishing to remain on AOM tirzepatide may face higher out-of-pocket costs or coverage denials
