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Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]
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Peer review Peer review information Nature Metabolism thanks Hamlet Gasoyan, Jason Halford and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Long-Term Safety Its uncertain if retatrutide is safe in the long term since its still being researched
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