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The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )
The preservation of nicotinamide substrate drastically increases the efficiency of the NAD+ salvage pathway
Long-term human safety data not established
It has at times been granted a food-ingredient designation, which is not the same as approval to treat a medical condition
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For people with serious deficiencies or absorption issues, this difference can be life-changing
