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Conversely, Ozempics dosage tops out at 2 mg weekly, optimized primarily for glycemic control in type 2 diabetes, though it also offers significant weight reduction

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In March 2024, Wegovy (semaglutide) was approved by the FDA to reduce the risk of major adverse cardiovascular events in adults with known heart disease and with obesity or overweight, in addition to a reduced calorie diet and increased physical activity

The LEADER cardiovascular outcomes trial demonstrated cardiovascular benefits, and subsequent analyses have shown reductions in inflammatory biomarkers

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Sitagliptin was the first agent introduced (in 2006) with other substances having followed soon after