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Preliminary human studies associate specific microbial signatures with mood states, and probiotic interventions are under investigation for mood stabilization by reducing systemic inflammation

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Other GLP-1 RA have also been approved but either no longer exist on the market or are not as frequently used

Alternative Therapies: Transitioning to other weight management medications or strategies if GLP-1s are no longer suitable

However, the heterogeneity of CKD may obscure disease-specific drug effects, underrepresent Alport patients, and delay the discovery of targeted therapies