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In mouse models, reduction of Aldh3a2 induced ferroptosis in leukemic cells and was synergistically lethal combined with the inhibitor of glutathione peroxidase 4 (GPX4) RSL3, whereas it was dispensable for normal hematopoiesis

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Finally, in a small nonrandomized, unblinded, controlled study in 42 obese children (mean age, 8 years) with MAFLD, lifestyle recommendations combined with 600 mg/day of supplemental RRR --tocopheryl acetate for six months reduced markers of oxidative stress and liver dysfunction and improved insulin sensitivity and the profile of lipid in the blood, when compared to baseline

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An agonist is a chemical that produces a biological response through activating the receptor