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Monitoring for Dysesthesia in Clinical Practice Baseline Assessment (Before Starting Retatrutide) Neurological Screening: Check for pre-existing neuropathy (diabetes, B12 deficiency) Document baseline sensation in hands/feet Review medications that affect nerves Assess risk factors (alcohol use, vitamin deficiencies) Patient Education: About 1 in 5 to 1 in 8 patients on the highest dose develop abnormal sensations like tingling or numbness (20.9% in TRIUMPH-4, 12.5% in TRIUMPH-1)

Endogenous synthesis requires adequate levels of vitamin C, iron, niacin, and vitamin B6 as cofactors

Fourthly, we used multiple imputation with chained equations to evaluate the influence of missing data on our findings for the following variables: smoking, body mass index, haemoglobin A 1c , and socioeconomic status (measured by the Index of Multiple Deprivation)

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doi: 10.1016/j.bbadis.2008.08.005 161 NeufeldtC