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A recent study further demonstrated that WBP1-deficient CRC cells regained sensitivity to 5-FU following the restoration of mitochondrial function [65], reinforcing a causal link between mitochondrial homeostasis and drug responsiveness

Metallodrugs can also be used as adjuvant drugs to enhance the efficacy of antiviral drugs (such as zinc plus hydroxychloroquine) [29,30,31] or used as vaccine adjuvants [32, 33]

This discovery is significant because LBP, a marker of bacterial translocation, reflects the hosts response to gut microbial translocation and circulating bacterial LPS (144)

This maintains consistent peptide levels without daily injection requirements