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Franjic, D
When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention
The 2022 Dimet-Wiley paper in Scientific Reports characterised NNMT inhibition combined with reduced-calorie diet in diet-induced-obesity mouse model systems (PMID 35013352)
Remethylation: Hcy turns back into methionine with folate, MTHFR, and vitamin B12
Copper also catalyses oxidative chemistry, so any reducing agent in the same solution deserves thought
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