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short-term ambient excursions during transit do not measurably affect potency

Peer review Peer review information Nature Communications thanks Toni Giorgino and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Clinical studies tested doses ranging from 250mcg to 1mg daily, with 300mcg showing effective fat reduction at the lowest side effect profile

The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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