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The evidence suggests they do not. Its unclear how certain peptides may impact the menstrual cycle, they point out

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Studies report protective outcomes in liver and pancreatic injury, periodontal damage, soft tissue trauma, and even neurological impairments, including conditions involving altered serotonergic and dopaminergic signaling

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Citation: Howard et al., Science, 1996

Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications