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Considering the good response to the first multimodal treatment, we decided to schedule subsequent treatment cycles of oral and topical treatment for 24 months, using the same agents and doses and reducing the frequency of peri-plaque penile injections with pentoxifylline 100 mg to one penile injection every month for 12 months (second cycle) and subsequently, we further reduced the frequency of penile injections to one injection every 2 months for 12 months (third cycle)

doi: 10.1074/jbc.M109.067207 98 KoehlerJADruckerDJ

For example: Easier impact on joints

The bruising results from minor trauma to small blood vessels beneath the skin during needle insertion, which is an inherent risk with any injectable medication

Biochem Biophys Res Commun 97: 10381046

A.SavasJ