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When GLP-1 is secreted from L-cells through the TGR5 agonist, it stimulates GLP-1R in enterochromaffin cells and induces serotonin or 5-hydroxytryptamine (5-HT) secretion from these cells

This leads to a brighter complexion and a reduction in the appearance of discoloration

For patients with a history of pancreatitis, FDA labeling advises considering other antidiabetic or weight management therapies, though this is not a formal contraindication

Targeted metabolomic profiling and prediction of cardiovascular events: a prospective study of patients with psoriatic arthritis and psoriasis