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In Mecp2e1-Bird mouse model of RTT [167], identified sex-differentiated early-life dysbiosis, marked by decreased Firmicutes, increased Bacteroidetes, and altered fecal metabolites (e.g., elevated SCFAs), detectable by five weeks of age, before the appearance of motor or behavioural symptoms in heterozygous females compared to males and wild-type controls

Shen HM, Pervaiz S

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Weight change typically becomes clearer over several weeks to months and depends on dose, diet, activity, sleep, and adherence