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GIP receptor activation complements these effects by promoting insulin secretion, while potentially improving insulin sensitivity in peripheral tissues and influencing lipid metabolism and energy expenditure, though these additional effects have more limited human data
Moreover, they show that metformin enhances the expression of the genes encoding the receptors for both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) in mouse islets and also increases the effects of GIP and GLP-1 on insulin secretion from beta cells
Drucker DJ, Brubaker PL
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