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For weight management, NICE recommends tirzepatide only within specialist weight management services for adults with a BMI of at least 35 kg/m (or at least 30 kg/m with weight-related comorbidities) and specific additional criteria

Clinical Pharmacology & Therapeutics , 110(2), 198-210

Smaller doses of GLP-1 RAs may not benefit those with severe metabolic dysfunction or those needing substantial weight loss

Many executives also believe that the FDA's announcement is not the end of the story and expect regulatory and legal action

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