Despite the growing use of these medications for obesity management, to our knowledge, no real-world evaluation has compared the effectiveness of tirzepatide and semaglutide in populations with the disease of obesity, without diabetes
Clinical studies indicate that stopping GLP-1 therapy abruptly can lead to weight regain due to hormonal and metabolic adaptations
Roberts BR, Ryan TM, Bush AI, Masters CL, Duce JA
A novel model of diabetic complications: adipocyte mitochondrial dysfunction triggers massive beta-cell hyperplasia
[1] [7] However, there are important considerations
indeed, it has been shown that mice genetically lacking miR-378 and miR-378* are resistant to high-fat-diet-induced obesity and display enhanced mitochondrial FA metabolism and elevated oxidative capacity of insulin-target tissue 90