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GLP-1R is concentrated in POMC/CART neurons of the arcuate nucleus, while GIPR is expressed on different neuronal subsets
FDA Concerns Regarding Compounded GLP-1 Medications The FDA has issued warnings regarding compounded GLP-1 drugs, highlighting several concerns [2]: Lack of Safety and Efficacy Review: Compounded drugs do not undergo FDA review for safety, effectiveness, or quality before being marketed
Not a standalone solution: GLP-1 should be used in conjunction with a reduced-calorie diet and increased physical activity to achieve the best results
Cell Proteomics 19 , 701715 (2020)
In contrast, GLP-1based therapies reshape satiety signaling more gradually and are used long-term
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