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Preclinical studies with SAR425899 clearly demonstrated dual receptor agonism in vitro and in preclinical in vivo studies, with a higher potency for the GLP1R than for the glucagon receptor in order to counterbalance the GCGR mediated increase of blood glucose levels through GLP-1 agonism 11,12,13

doi: 10.3389/fphar.2025.1675552 Received 29 July 2025 Accepted 28 August 2025 Published 11 September 2025 Volume 16 - 2025 Edited by Claudia Manca, University of Cagliari, Italy Reviewed by Basveshwar Gawali, Washington University in St

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