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JAMA , 314(7), 687-699

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It works by attaching to IGF-1 receptors on cells, which then activate key internal cell pathways, including PI3K-Akt and MAPK

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How Microdosing works in practice If you and your provider decide that microdosing is appropriate, the process usually begins simply: start at the lowest available dose, typically 0.25 mg per week