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Because NAC simultaneously prompts mast cells to release histamine and prevents the body from breaking that histamine down, it can trigger severe symptom flaressuch as hives, sinus drainage, anxiety, and flushingin highly sensitive MCAS patients
doi: 10.1002/hep.27060 151 BoparaiRKArumOMiquetJGMasternakMMBartkeAKhardoriRK
It is often used in sports nutrition because of its potential to help with muscle soreness and physical recovery
3f), suggesting that upregulation of GSH biosynthesis might have a functionality in counteracting the increase in ROS
Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress