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Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo

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A transwell 3D liver co-culture model including non-parenchymal cells and human primary hepatocytes showed that treatment with TVX 25 M resulted in increased LDH release after 8 days with associated decrease in cellular viability 39

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