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Effect of glutathione on ribonuclease

falciparum has no identified Nrf2 orthologue and so likely lacks a KEAP1-Nrf2 mediated antioxidant response, which suggests that the SFN-GSH conjugate should only cause oxidative stress in parasites

Glutathione is considered safe when taken orally in doses up to 500 mg daily for up to 2 months

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Although further study of these interactions is necessary, patients receiving these agents concurrently should be monitored for the desired therapeutic response to vitamin B12