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PMID: 36304787

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10,15,53 For example, human ER is homologous to ER, particularly in the DNA-binding domain (97% amino acid identity), but share little homology in the other domains (such as in the ligand-binding region), where one would predict that 17-estradiol would display different affinities for the ERs, but surprisingly, it has almost equal high affinity for ER and for ER

However, MT-II administration partially reversed this effect

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