glutathione inhibitor LCS3 is a Disulfide Reductase (GSR) and TXNRD1 glutathione synthetase inhibitor Role of

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Moreover, the expression of key spermatogenesis markers, including UCHL1, PLZF, SCP3, and PCNA, which were reduced in aged testes, were significantly restored or increased following FOXO4-DRI treatment

The authors conclude that the indicated SOD2 and SOD3 polymorphisms may be genetic risk factors for the susceptibility and progression of vitiligo suggesting the increased activity of SOD isoforms caused by the variant gene polymorphisms may lead to the accumulation of H 2 O 2 in cytoplasmic, mitochondrial and extracellular compartments resulting in melanocyte oxidative damage