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Clinical trials confirmed no effect on serum IGF-1, no negative impact on carbohydrate metabolism, and excellent tolerability with safety profile indistinguishable from placebo
PMID 19625176
Freezing gives the best balance of cost and safety
Plain silymarin is poorly absorbed
doi: 10.1016/S0140-6736(14)61375-1 26 PivonelloRDe MartinoMCDe LeoMLombardiGColaoA
Patients who are pregnant or breastfeeding, who have known sulphur or sulphite sensitivity, or who have certain medical conditions may need to defer or avoid treatment
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