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Clinical implications The diagnostic performance of thalamic GSH (AUC = 0.879) in this exploratory analysis suggests it warrants further investigation as a potential candidate diagnostic marker

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doi: 10.1111/jpn.13759

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Foundational Characterisation The synthesis and initial characterisation of Melanotan 1 by Hadley and Dorr at the University of Arizona established it as a potent, stable MC1R agonist with substantially enhanced in vivo bioactivity compared to native -MSH, and confirmed its capacity to stimulate melanogenesis in pre-clinical models

Acknowledgements The authors acknowledge funding support from the New Zealand Ministry of Business, Innovation & Employment Hkina Whakatutuki (UOAX1809