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Creatine supplementation can increase serum creatinine levels independently of true kidney function, potentially affecting eGFR readings

Nature 499 , 438443 (2013) Wootten, D., Simms, J., Miller, L

This parallels the fatigue reported with GLP-1 agonists and semaglutide-specific tiredness

But while these effects work incredibly well for managing weight, having that partially digested food still sitting in your system is exactly what creates complications when it's time for anesthesia

Chan LP, Gee R, Keogh C, Munk PL

[11] Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), [12] especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress